Human Growth Hormone is more powerful than thought

Everyone is no stranger to Human Growth Hormone: it is secreted by the pituitary gland and plays an important role in cell regeneration, growth and maintenance of body health.

The history of human research on Human Growth Hormone has been more than a hundred years, and the synthetic Human Growth Hormone by genetic recombination has been available for 30 years and has been approved for use by the FDA. Growth hormone is very effective in promoting fat loss.

Experiments have shown that ghrelin can accelerate fat metabolism by promoting the hydrolysis of triglycerides, but if ghrelin is lacking, the body's ability to metabolize fat will be greatly weakened.

An empirical study was published in Hormone Research, an internationally renowned journal of hormone research: 24 obese subjects were given a low-calorie diet, half of which received exogenous growth hormone treatment, and the other half received placebo treatment.

The experiment was conducted in a double-blind design for a period of 12 weeks. The experimental results found that the rate of fat loss in the growth hormone group was 1.6 times that of the placebo group, and the visceral fat reduction was extremely significant.

In terms of lean body mass, the lean body mass of the subjects in the placebo group decreased significantly, but the ghrelin group not only did not reduce the lean body mass but also increased it (it should be noted that the dietary arrangement in this experiment is low-calorie, natural conditions cannot increase lean body mass). This is a great boon for anyone worried about losing muscle when losing fat.

The experimental results strongly demonstrate the powerful effect of ghrelin in reducing weight, not only that, but it also has a significant muscle-building effect, and the onset of action is much faster than generally believed.

GH1-related genes

The human genome contains 5 GH-related genes: Human Growth Hormone (hGH), Human Chorionic Growth Prolactin-A (hCS-A), Human Chorionic Growth Prolactin-B (hCS-B), Human Chorionic Growth Prolactin analog (hCS-L), human growth hormone variant (hGH-V) [1]. Their order of 5'-3' is: hGH1, hCS-L, hCS-A, hGH-V and hCS-B.

They are transcribed in the same direction but separated by intergenic spacers 6-13 kb long, respectively.

The five genes have about 91% to 99% sequence homology, and each gene contains 5 exons and 4 introns.

Five genes are linked together to form a gene cluster, which is located on the long arm q22-24 of chromosome 17, with a total length of 66.5 kb.

Regulators of Human Growth Hormone

Several molecular isoforms of growth hormone are secreted by the pituitary gland and released into the bloodstream.

GH is secreted in a pulsatile manner, and its secretion is fluctuating, with the largest change at night, the most vigorous secretion during puberty, and then gradually decreasing with age.

The secretion of growth hormone (GH) in the pituitary gland is controlled by two hypothalamic peptides: GH-releasing hormone (GHRH) and growth hormone-releasing inhibitory hormone factor (SRIF).

GHRH is the main regulator of GH, promoting the transcription and release of GH gene; somatostatin inhibits the secretion of growth hormone by inhibiting the growth nutrient response of growth hormone to GHRH.

The third factor is ghrelin, which has a stimulating effect on growth hormone secretion, although its role in the physiological regulation of growth hormone secretion is controversial.