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Mary
Mary
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Androgen Index 37
Anabolic Index 125
Maternal hormone testosterone
Chemical Name 19-norandrost-4-en-3-one-17beta-ol, 17beta-hydroxy-estr-4-en-3-one
Low estrogen activity
Progesterone activity moderate
bioavailability
Oral: 0.3-2.9% (pig)
Intramuscular injection: high
Metabolic pathway Metabolizes blood (hydrolysis), liver (reduction)
metabolite
• Nandrolone
• 5α-Dihydronandrolone
• 19-Norandrosterone
• 19-Noretiocholanolone
• Conjugates
Half-life 2.7 days
Duration 5-7 days
Excretion route Urine
Introduction to Nandrolone Phenylpropionate:
Durabolin is the trade name of Nandrolone Phenylpropionate, which is often confused with Deca-Durabolin, both of which belong to Nandrolone and can also be called Deka and Deca-Durabolin. Ling is nandrolone decanoate, and Durabolin is nandrolone phenylpropionate, both of which have different ester chains. The properties of this drug are essentially the same as those of Deca-Durabolin®, except for the ester chain, which uses a caprate ester. The main difference between the two formulations is the speed at which nandrolone is released into the bloodstream. While nandrolone decanoate provided a release of nandrolone from the injected area that lasted about 3 weeks, nandrolone phenylpropionate was only for one week. In a clinical setting, Deca-Durabolin can therefore be injected every 2 or 3 weeks, while Nandrolone Phenylpropionate Durabolin is usually injected every few days to weekly. Otherwise, the two drugs are pretty much interchangeable.
Nandrolone Phenylpropionate History:
Nandrolone phenylpropionate was first developed and marketed in 1957. Soon after, it became a prescription drug sold under the brand name Durabolin by international pharmaceutical giant Organon (now Merck/MSD). When first introduced to the U.S., Nandrolone Phenylpropionate was used for pre- and postoperative lean mass preservation, osteoporosis, advanced breast cancer, weight loss due to rehabilitation or disease, geriatric states (generalized weakness and frailty), burns , Severe trauma, ulcers, adjunctive treatment of some forms of anemia, and selected cases of growth retardation in children. In the 1970s, the FDA began to revise the drug's designation, and its scope soon narrowed significantly. Going forward, the drug is primarily used to treat advanced metastatic breast cancer, and Durabolin is the focus of Organon's marketing efforts, only less than a decade after its release. Another version, Decadol was introduced in the 1960s, and Nandrolone Phenylpropionate, although still available, began to take a back seat. However, nandrolone phenylpropionate was not completely abandoned by Organon at the time, in part because some countries had slightly different therapeutic uses and thus continued to dominate the market for some time. As the size of the anabolic steroid market continued to grow throughout the 1970s and 1980s, Nandrolone Decanoate attracted the most attention from other drug manufacturers, and Nandrolone Phenylpropionate became less competitive in the market.
Nandrolone Phenylpropionate Common Specifications:
Common strengths of nandrolone phenylpropionate are: 25 mg/mL or 50 mg/mL. The common preparations on the market are oil preparations of 100-200mg/ml
Structural characteristics of Nandrolone Phenylpropionate: Illustration: (middle) http://xiezuo.oss-cn-shanghai.aliyuncs.com/579651/picture1552915951628-91.png
Nandrolone phenylpropionate is a modified form of nandrolone in which the phenylpropionate ester is attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids and are absorbed more slowly from the injection area. Once in the bloodstream, the ester is removed to give free (active) nandrolone. Esterified steroids are designed to prolong the window of therapeutic effect after administration, and may be injected less frequently than free (unesterified) steroids. Nandrolone phenylpropionate was released and peaked in serum within 24-48 hours after deep intramuscular injection and declined to near baseline levels within a week.
Nandrolone phenylpropionate has many positive features similar to many anabolic steroids. However, this compound also has functional properties that go far beyond those of some steroid hormones. Positive functional characteristics of nandrolone phenylpropionate include:
Increased IGF-1 Production: Insulin-like growth factor-1 (IGF-1) is a potent anabolic hormone that is also essential to our body's ability to recover. This is a hormone that affects almost all cells in the body.
Suppresses glucocorticoids: These hormones are called stress hormones (cortisol) and are vital to our health and well-being. However, when glucocorticoids become dominant, they can also promote muscle loss and fat gain. Strenuous activity can lead to an increase in stress hormones. Hormones like Nandrolone can reduce the production of stress hormones.
Increased Nitrogen Retention: All muscle tissue consists of 16% nitrogen. If retention drops, we're stuck in a catabolic state. The more we keep, the more anabolic we keep.
Increased protein synthesis: This refers to the rate at which cells build proteins, the building blocks of muscle tissue.
Increased red blood cell count: Red blood cells carry oxygen into and through the blood. Greater efficiency improves muscular endurance and recovery.
Increases collagen synthesis and bone mineral content: This refers to the strength of bones and cartilage and the ability to strengthen and provide healing relief. This will apply to joints more than anywhere else.
Use of Nandrolone Phenylpropionate:
For an off-season athlete, Nandrolone Phenylpropionate is one of the best steroids he can choose to build muscle and gain weight during an off-season cycle. This is one of the best growth steroids and most bodybuilders put him in their off-season programs. Although this is a very fast nandrolone ester chain in the nandrolone family, the growth will not happen quickly, but it will be stable, uniform and significant. This is assuming you eat enough. For muscle growth, there is no steroid in the world that can change this truth. However, if you take every step seriously and correctly, you will get more out of a steroid like Nandrolone Phenylpropionate in a perfect way. Nandrolone Phenylpropionate can also be used in a race preparation or fat loss cycle, although it is generally considered unfavorable to schedule in a race preparation and fat loss cycle. But nandrolone phenylpropionate will protect lean muscle mass better than many steroids. When we diet, we have to consume more calories than we eat. This is the only way to lose body fat. Unfortunately, this puts our muscle tissue at risk. Usually some fat loss is also accompanied by some of our muscle loss. A successful and perfect diet plan can also limit this loss, and Nandrolone can provide this protection. Many athletes use low-dose nandrolone phenylpropionate to help with recovery and reduce joint stress. These are not narcotic like painkillers, but real relief.
Nandrolone Phenylpropionate Side Effects (estrogen):
Nandrolone has a lower tendency to convert estrogen and is estimated to be only about 20% of that of testosterone. This is because, although the liver can convert nandrolone to estrogen, aromatizing steroids have more active sites in adipose tissue than aromatizing steroids, and there are fewer nandrolone-to-estrogen pathways. many. Therefore, this drug has far fewer estrogen-related side effects than testosterone. However, elevated estrogen levels can still be noticed at higher doses and may cause side effects such as water storage, increased body fat, and gynecomastia. If they occur, anti-estrogen drugs such as clomiphene or tamoxifen may be needed to prevent estrogen side effects. Aromatase inhibitors such as anastrozole (Arimidex) may alternatively be used, which control estrogen more effectively by preventing estrogen synthesis. However, aromatase inhibitors can be quite expensive compared to the aforementioned antiestrogens and can also have negative effects on blood lipids.
Notably, Nandrolone has some activity as a progestin in the body. Although progesterone is a C-19 steroid, many C-19 anabolic steroids also show some affinity for the progesterone receptor. Side effects associated with progesterone are similar to those of estrogen, including suppression of the HPTA hypothalamus and fat storage. Progesterone also enhances the stimulating effect of estrogen on breast tissue growth. There is also a strong synergy between these two hormones, so gynecomastia may even be catalyzed by the synergy of progestins without excessive estrogen levels, the use of anti-estrogens is usually sufficient to alleviate the effects of nandrolone Gynecomastia.
Nandrolone Phenylpropionate Side Effects (Androgens):
Nandrolone phenylpropionate may have androgenic side effects, but it is not very likely in men. Hair loss in men prone to male pattern baldness is possible, as is acne in sensitive men. However, when it comes to this effect, this is one of the most tolerated steroids of all people. Genetic predisposition will play the biggest role.
Additionally, in androgen-responsive target tissues such as skin, scalp and prostate, the relative androgenicity of nandrolone is reduced by its reduction to DHN. 5-alpha reductase is responsible for the metabolism of this nandrolone. Concomitant use of 5-alpha reductase inhibitors such as finasteride or dutasteride interferes with the site-specific reduction of nandrolone, and instead greatly increases the tendency of nandrolone to produce androgenic side effects.
Nandrolone Phenylpropionate Side Effects (Hepatotoxicity):
Nandrolone phenylpropionate is not a c-17α alkylated steroid, and no hepatotoxicity has been found in clinical testing. It is unlikely that nandrolone phenylpropionate is hepatotoxic.
Nandrolone Phenylpropionate Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift HDL toward LDL balance, increasing the risk of arteriosclerosis. The effect of anabolic/androgenic steroids on blood lipids depends on dose, route of administration (oral vs. injection), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. A study using nandrolone decanoate 600mg weekly for 10 weeks showed a 26% reduction in HDL cholesterol levels. This inhibitory effect was slightly higher than reported for an equivalent dose of testosterone enanthate, and was consistent with earlier studies showing a slightly stronger negative effect on HDL/LDL ratios for nandrolone decanoate compared to nandrolone decanoate. However, the effect of nandrolone on serum lipids was still significantly lower than that of c-17α alkylating drugs.
Nandrolone Phenylpropionate Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids suppress endogenous testosterone production when taken in doses sufficient to promote muscle gain. A study using 100 mg of nandrolone phenylpropionate showed rapid suppression of serum testosterone after a single injection. On day 3 post-dose, testosterone levels dropped to about 30% of initial levels and remained suppressed for about 13 days. Regular use is expected to significantly prolong the endogenous hormone recovery window.
Dosage of Nandrolone Phenylpropionate
For general therapeutic pathway anabolic effects, early prescribing guidelines recommend a weekly dose of 25-50 mg for 12 weeks. The usual dose for muscle growth or athletic performance improvement is 200-400 mg per week in cycles of 8 to 12 weeks. Note that due to the fast-acting nature of phenylpropionate, the weekly dose is usually subdivided into 2 evenly spaced separate applications.
About female use
For general anabolic effects, early prescribing guidelines recommend a dose of 25-50 mg per week for 12 weeks. The usual dose for muscle growth or athletic performance improvement is a dose of 50 mg per week (administered as a weekly injection) which is most common in cycles of 4 to 6 weeks. Higher doses or longer durations of use are discouraged due to potential androgenic side effects. Although only mildly androgenic, women occasionally experience virilization symptoms when using this compound. If virilizing side effects become a problem, nandrolone phenylpropionate should be discontinued immediately.
Product Manual:
Androgen Index 37
Anabolic Index 125
Maternal hormone testosterone
Chemical Name 19-norandrost-4-en-3-one-17beta-ol, 17beta-hydroxy-estr-4-en-3-one
Low estrogen activity
Progesterone activity moderate
bioavailability
Oral: 0.3-2.9% (pig)
Intramuscular injection: high
Metabolic pathway Metabolizes blood (hydrolysis), liver (reduction)
metabolite
• Nandrolone
• 5α-Dihydronandrolone
• 19-Norandrosterone
• 19-Noretiocholanolone
• Conjugates
Half-life 2.7 days
Duration 5-7 days
Excretion route Urine
Introduction to Nandrolone Phenylpropionate:
Durabolin is the trade name of Nandrolone Phenylpropionate, which is often confused with Deca-Durabolin, both of which belong to Nandrolone and can also be called Deka and Deca-Durabolin. Ling is nandrolone decanoate, and Durabolin is nandrolone phenylpropionate, both of which have different ester chains. The properties of this drug are essentially the same as those of Deca-Durabolin®, except for the ester chain, which uses a caprate ester. The main difference between the two formulations is the speed at which nandrolone is released into the bloodstream. While nandrolone decanoate provided a release of nandrolone from the injected area that lasted about 3 weeks, nandrolone phenylpropionate was only for one week. In a clinical setting, Deca-Durabolin can therefore be injected every 2 or 3 weeks, while Nandrolone Phenylpropionate Durabolin is usually injected every few days to weekly. Otherwise, the two drugs are pretty much interchangeable.
Nandrolone Phenylpropionate History:
Nandrolone phenylpropionate was first developed and marketed in 1957. Soon after, it became a prescription drug sold under the brand name Durabolin by international pharmaceutical giant Organon (now Merck/MSD). When first introduced to the U.S., Nandrolone Phenylpropionate was used for pre- and postoperative lean mass preservation, osteoporosis, advanced breast cancer, weight loss due to rehabilitation or disease, geriatric states (generalized weakness and frailty), burns , Severe trauma, ulcers, adjunctive treatment of some forms of anemia, and selected cases of growth retardation in children. In the 1970s, the FDA began to revise the drug's designation, and its scope soon narrowed significantly. Going forward, the drug is primarily used to treat advanced metastatic breast cancer, and Durabolin is the focus of Organon's marketing efforts, only less than a decade after its release. Another version, Decadol was introduced in the 1960s, and Nandrolone Phenylpropionate, although still available, began to take a back seat. However, nandrolone phenylpropionate was not completely abandoned by Organon at the time, in part because some countries had slightly different therapeutic uses and thus continued to dominate the market for some time. As the size of the anabolic steroid market continued to grow throughout the 1970s and 1980s, Nandrolone Decanoate attracted the most attention from other drug manufacturers, and Nandrolone Phenylpropionate became less competitive in the market.
Nandrolone Phenylpropionate Common Specifications:
Common strengths of nandrolone phenylpropionate are: 25 mg/mL or 50 mg/mL. The common preparations on the market are oil preparations of 100-200mg/ml
Structural characteristics of Nandrolone Phenylpropionate: Illustration: (middle) http://xiezuo.oss-cn-shanghai.aliyuncs.com/579651/picture1552915951628-91.png
Nandrolone phenylpropionate is a modified form of nandrolone in which the phenylpropionate ester is attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids and are absorbed more slowly from the injection area. Once in the bloodstream, the ester is removed to give free (active) nandrolone. Esterified steroids are designed to prolong the window of therapeutic effect after administration, and may be injected less frequently than free (unesterified) steroids. Nandrolone phenylpropionate was released and peaked in serum within 24-48 hours after deep intramuscular injection and declined to near baseline levels within a week.
Nandrolone phenylpropionate has many positive features similar to many anabolic steroids. However, this compound also has functional properties that go far beyond those of some steroid hormones. Positive functional characteristics of nandrolone phenylpropionate include:
Increased IGF-1 Production: Insulin-like growth factor-1 (IGF-1) is a potent anabolic hormone that is also essential to our body's ability to recover. This is a hormone that affects almost all cells in the body.
Suppresses glucocorticoids: These hormones are called stress hormones (cortisol) and are vital to our health and well-being. However, when glucocorticoids become dominant, they can also promote muscle loss and fat gain. Strenuous activity can lead to an increase in stress hormones. Hormones like Nandrolone can reduce the production of stress hormones.
Increased Nitrogen Retention: All muscle tissue consists of 16% nitrogen. If retention drops, we're stuck in a catabolic state. The more we keep, the more anabolic we keep.
Increased protein synthesis: This refers to the rate at which cells build proteins, the building blocks of muscle tissue.
Increased red blood cell count: Red blood cells carry oxygen into and through the blood. Greater efficiency improves muscular endurance and recovery.
Increases collagen synthesis and bone mineral content: This refers to the strength of bones and cartilage and the ability to strengthen and provide healing relief. This will apply to joints more than anywhere else.
Use of Nandrolone Phenylpropionate:
For an off-season athlete, Nandrolone Phenylpropionate is one of the best steroids he can choose to build muscle and gain weight during an off-season cycle. This is one of the best growth steroids and most bodybuilders put him in their off-season programs. Although this is a very fast nandrolone ester chain in the nandrolone family, the growth will not happen quickly, but it will be stable, uniform and significant. This is assuming you eat enough. For muscle growth, there is no steroid in the world that can change this truth. However, if you take every step seriously and correctly, you will get more out of a steroid like Nandrolone Phenylpropionate in a perfect way. Nandrolone Phenylpropionate can also be used in a race preparation or fat loss cycle, although it is generally considered unfavorable to schedule in a race preparation and fat loss cycle. But nandrolone phenylpropionate will protect lean muscle mass better than many steroids. When we diet, we have to consume more calories than we eat. This is the only way to lose body fat. Unfortunately, this puts our muscle tissue at risk. Usually some fat loss is also accompanied by some of our muscle loss. A successful and perfect diet plan can also limit this loss, and Nandrolone can provide this protection. Many athletes use low-dose nandrolone phenylpropionate to help with recovery and reduce joint stress. These are not narcotic like painkillers, but real relief.
Nandrolone Phenylpropionate Side Effects (estrogen):
Nandrolone has a lower tendency to convert estrogen and is estimated to be only about 20% of that of testosterone. This is because, although the liver can convert nandrolone to estrogen, aromatizing steroids have more active sites in adipose tissue than aromatizing steroids, and there are fewer nandrolone-to-estrogen pathways. many. Therefore, this drug has far fewer estrogen-related side effects than testosterone. However, elevated estrogen levels can still be noticed at higher doses and may cause side effects such as water storage, increased body fat, and gynecomastia. If they occur, anti-estrogen drugs such as clomiphene or tamoxifen may be needed to prevent estrogen side effects. Aromatase inhibitors such as anastrozole (Arimidex) may alternatively be used, which control estrogen more effectively by preventing estrogen synthesis. However, aromatase inhibitors can be quite expensive compared to the aforementioned antiestrogens and can also have negative effects on blood lipids.
Notably, Nandrolone has some activity as a progestin in the body. Although progesterone is a C-19 steroid, many C-19 anabolic steroids also show some affinity for the progesterone receptor. Side effects associated with progesterone are similar to those of estrogen, including suppression of the HPTA hypothalamus and fat storage. Progesterone also enhances the stimulating effect of estrogen on breast tissue growth. There is also a strong synergy between these two hormones, so gynecomastia may even be catalyzed by the synergy of progestins without excessive estrogen levels, the use of anti-estrogens is usually sufficient to alleviate the effects of nandrolone Gynecomastia.
Nandrolone Phenylpropionate Side Effects (Androgens):
Nandrolone phenylpropionate may have androgenic side effects, but it is not very likely in men. Hair loss in men prone to male pattern baldness is possible, as is acne in sensitive men. However, when it comes to this effect, this is one of the most tolerated steroids of all people. Genetic predisposition will play the biggest role.
Additionally, in androgen-responsive target tissues such as skin, scalp and prostate, the relative androgenicity of nandrolone is reduced by its reduction to DHN. 5-alpha reductase is responsible for the metabolism of this nandrolone. Concomitant use of 5-alpha reductase inhibitors such as finasteride or dutasteride interferes with the site-specific reduction of nandrolone, and instead greatly increases the tendency of nandrolone to produce androgenic side effects.
Nandrolone Phenylpropionate Side Effects (Hepatotoxicity):
Nandrolone phenylpropionate is not a c-17α alkylated steroid, and no hepatotoxicity has been found in clinical testing. It is unlikely that nandrolone phenylpropionate is hepatotoxic.
Nandrolone Phenylpropionate Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift HDL toward LDL balance, increasing the risk of arteriosclerosis. The effect of anabolic/androgenic steroids on blood lipids depends on dose, route of administration (oral vs. injection), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. A study using nandrolone decanoate 600mg weekly for 10 weeks showed a 26% reduction in HDL cholesterol levels. This inhibitory effect was slightly higher than reported for an equivalent dose of testosterone enanthate, and was consistent with earlier studies showing a slightly stronger negative effect on HDL/LDL ratios for nandrolone decanoate compared to nandrolone decanoate. However, the effect of nandrolone on serum lipids was still significantly lower than that of c-17α alkylating drugs.
Nandrolone Phenylpropionate Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids suppress endogenous testosterone production when taken in doses sufficient to promote muscle gain. A study using 100 mg of nandrolone phenylpropionate showed rapid suppression of serum testosterone after a single injection. On day 3 post-dose, testosterone levels dropped to about 30% of initial levels and remained suppressed for about 13 days. Regular use is expected to significantly prolong the endogenous hormone recovery window.
Dosage of Nandrolone Phenylpropionate
For general therapeutic pathway anabolic effects, early prescribing guidelines recommend a weekly dose of 25-50 mg for 12 weeks. The usual dose for muscle growth or athletic performance improvement is 200-400 mg per week in cycles of 8 to 12 weeks. Note that due to the fast-acting nature of phenylpropionate, the weekly dose is usually subdivided into 2 evenly spaced separate applications.
About female use
For general anabolic effects, early prescribing guidelines recommend a dose of 25-50 mg per week for 12 weeks. The usual dose for muscle growth or athletic performance improvement is a dose of 50 mg per week (administered as a weekly injection) which is most common in cycles of 4 to 6 weeks. Higher doses or longer durations of use are discouraged due to potential androgenic side effects. Although only mildly androgenic, women occasionally experience virilization symptoms when using this compound. If virilizing side effects become a problem, nandrolone phenylpropionate should be discontinued immediately.
Product Manual:
