Toxicology of GH human growth hormone drugs

Human growth hormone is a peptide hormone composed of 191 amino acids secreted by growth hormone (GH) secreting cells containing eosinophilic granules in the anterior pituitary.

This product is a recombinant human growth hormone(rhGH) produced by gene recombinant Escherichia coli secretory expression technology. Its amino acid content and sequence are exactly the same as that of human growth hormone.

This product is synthesized in E. coli. Synthesis is carried out by pre hormone. The prohormone is composed of growth hormone naturally existing in bacteria and connected with signal peptide.

Prohormone splits in the inner wall of the bacterial cell, releases the end product exactly the same as natural growth hormone into the wall membrane gap, and then only destroys the outer wall of the cell to collect, while the inner wall of the cell remains intact, so as to ensure that very few bacterial proteins pollute the end product.

Secretory recombinant human growth hormone (rhGH) has the same effect as human endogenous growth hormone. It stimulates the differentiation and proliferation of epiphyseal chondrocytes, the growth of cartilage stromal cells, the differentiation and proliferation of osteoblasts, and causes linear growth acceleration and bone widening.

Promote systemic protein synthesis, correct the negative nitrogen balance after trauma such as surgery, and correct hypoproteinemia caused by severe infection and liver cirrhosis.

Stimulate the synthesis of immunoglobulin, stimulate the proliferation of lymphoid tissue, macrophages and lymphocytes, and enhance the anti infection ability;

Stimulate collagen somatic cells to synthesize fibroblasts, macrophages to divide and proliferate, accelerate wound healing, promote myocardial protein synthesis, increase myocardial contractility, reduce myocardial oxygen consumption, regulate fat metabolism, and reduce the levels of serum cholesterol and low-density lipoprotein; Supplement growth hormone deficiency or deficiency, regulate adult fat metabolism, bone metabolism, heart and kidney function.

According to the literature, subcutaneous or intramuscular injection has the same effect. Subcutaneous injection usually brings higher serum GH concentration than intramuscular injection, but the concentration of insulin-like growth factor I (IGF-I) is the same.

GH absorption is usually slow, and plasma GH concentration usually reaches a peak 3-5 hours after administration.

The clearance half-life is generally 2-3 hours. GH is cleared through the liver and kidney, and adults are faster than children; The unmetabolized GH directly excluded from urine is extremely trace.

In blood circulation, almost all GH binds to high affinity GH binding protein (hGHbp). This complex prolongs the half-life of GH in serum. Different injection times in a day will not affect the concentration of GH in serum.